A Convenient route for the synthesis of antimicrobial 1, 3, 4- thiadiazole derivatives

Authors

  • AD Mishra Dept. of Chemistry, Tribhuvan University, P. N. Campus, Pokhara

DOI:

https://doi.org/10.3126/bibechana.v8i0.4766

Keywords:

Aminobenzothiazole, 1, 3, 4- thiadiazole, antimicrobial, cyclization

Abstract

  Thiosemicarbazide of 6-chloro-2- aminobenzothiazole on cyclization with different aromatic carboxylic acids in Phosphorus oxychloride provided the corresponding 2-aryl-5-(6’-chloro-1’,3’-benzothiazole-2-yl-amino)-1,3,4-thiadiazoles 4a-j. The compounds are characterized by elemental analysis, IR and 1H NMR spectral data. All the compounds are evaluated in vitro for their antimicrobial activities against several fungal and bacterial strains and showed significant activities.

Keywords: Aminobenzothiazole; 1, 3, 4- thiadiazole; antimicrobial; cyclization

DOI: http://dx.doi.org/10.3126/bibechana.v8i0.4766

BIBECHANA 8 (2012) 17-22

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Published

2012-01-15

How to Cite

Mishra, A. (2012). A Convenient route for the synthesis of antimicrobial 1, 3, 4- thiadiazole derivatives. BIBECHANA, 8, 17–22. https://doi.org/10.3126/bibechana.v8i0.4766

Issue

Vol. 8 (2012)

Section

Research Articles

License

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