Association between serum albumin and cardiovascular diseases among adult population of Kaski district, Nepal

Authors

  • Naval Kishor Yadav Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal
  • Daya Ram Pokharel Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal
  • Goma Kathayat Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal
  • Manoj Sigdel Department of Biochemistry, Manipal College of Medical Sciences, Pokhara, Nepal
  • Imran Hussain School of Life and Allied Health Sciences, Glocal University, Saharanpur, Uttar Pradesh, India

DOI:

https://doi.org/10.3126/acclm.v4i1.42678

Keywords:

Serum albumin, Cardiovascular diseases, Cardiovascular risk factors

Abstract

Background: Serum albumin is an abundant circulatory protein. Several studies were reported that a low level of serum albumin associated with a high risk of cardiovascular diseases (CVDs) mortality. Therefore, the present study aimed to investigate serum albumin levels and find out the association between serum albumin and CVDs and their correlation with cardiovascular risk factors.

Methods: This was a cross-sectional study. Patients with confirmed CVDs were enrolled in this study while patients with CVDs plus acute or chronic liver and intestinal diseases were excluded in this study. Data were collected and analyzed by using SPSS version 21. P-value (two-tailed) < 0.05 was considered statistically significant.

Results: A total of 400 subjects were enrolled, out of which 200 healthy control (male 125 and female 75) and 200 patients with CVDs (male 130 and female 70). The mean level of total protein, albumin, globulin, and HDL-C were statistically (p<0.005) lower while TC, TG, and FBS were statistically (p<0.005) higher in CVDs sub-jects in compared to healthy control. The serum albumin was lower in 35 (17.5%) of patients with CVDs, out of which 19 (9.5%) were male and 16 (8.0%) were female. Serum albumin showed a statistically significant negative correlation with age (p=0.000) and a positive correlation with TC (p=0.000). In multinomial logistic regression analysis, model-I, II, and III showed a statistically significant (p<0.05) association between serum albumin with CVDs.

Conclusion: This study concluded, low serum albumin was found in patients with CVDs and it was significantly associated with CVDs. Therefore, measurement of serum albumin can be performed routinely in patients with CVDs.

Downloads

Download data is not yet available.
Abstract
375
PDF
571
Cover ACCLM

Downloads

Published

2021-12-31

How to Cite

Yadav, N. K., Pokharel, D. R., Kathayat, G., Sigdel, M., & Hussain, I. (2021). Association between serum albumin and cardiovascular diseases among adult population of Kaski district, Nepal. Annals of Clinical Chemistry and Laboratory Medicine, 4(1), 26–30. https://doi.org/10.3126/acclm.v4i1.42678

Issue

Vol. 4 No. 1 (2021)

Section

Original Articles

License

Copyright (c) 2021 Nepalese Association for Clinical Chemistry

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. The author transfers copyright to the Nepalese Association for Clinical Chemistry.
  2. The journal publishes the work under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal and under the same share-alike license used here.
  3. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).